【 中文摘要 】本發明公開了一種抗術後腫瘤複發的免疫輔助貼片及其制備方法。該貼片以親水性殼聚糖爲基質，免疫活性組分與基質溶解分散混合均勻後置于模具内凝固成型而成；所述免疫活性組分爲免疫抗體和免疫佐劑。本發明制備的免疫輔助貼片，借助親水性醫用殼聚糖，靜電吸附帶正電且具備酸調控特性和抗腫瘤免疫佐劑特性的LDHs功能納米材料，靜電吸附攜帶豐富氨基且能夠逆轉腫瘤免疫抑制的治療性抗體，最終組裝成傷口生理條件下可解體的生物功能貼片。本發明具備應用安全、性能優異的特點，有望作爲新型術後免疫輔助方案，推動腫瘤治愈并惠及患者，改善術後患者的長期生存率和生存質量。

【 英文摘要 】The invention discloses an immune auxiliary patch for resisting postoperative tumor recurrence and a preparation method thereof. Said patch uses hydrophilic chitosan as matrix, and the immunoactive component and matrix are dissolved, dispersed and uniformly mixed, then placed in the mould and solidified and formed so as to obtain the invented product. The immune active components are immune antibody and immune adjuvant. The immune assistant paster prepared by the present invention By means of hydrophilic medical chitosan and electrostatic adsorption of positively charged LDHs functional nano-material with acid regulation and control characteristics and anti-tumor immune adjuvant characteristics, and electrostatic adsorption of therapeutic antibody carrying rich amino groups and capable of reversing tumor immunosuppression, the biological functional patch capable of being disintegrated under wound physiological conditions is finally assembled. The invention has the characteristics of safe application and excellent performance, and is expected to be used as a novel postoperative immune auxiliary scheme to promote tumor healing, benefit patients and improve the long-term survival rate and life quality of postoperative patients.

[ 英文標題 ]

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【 首項權利要求-原文 】

1.一種免疫輔助貼片，其特征在于，該貼片以親水性殼聚糖爲基質，免疫活性組分與基質溶解分散混合均勻後置于模具内凝固成型而成；所述免疫活性組分爲免疫抗體和免疫佐劑。

【 首項權利要求-翻譯 】

1. An immune auxiliary patch, wherein the patch uses hydrophilic chitosan substrate, immune active component and matrix dissolving and dispersing and mixing uniformly, then placing in the mould and solidifying to form, the immune active component is immune antibody and immunologic adjuvant.